High CPU and Disk I/O primarily caused by MsMpEng.exe?

For some reason when I go in here I can see

  1. Windows Defender Antivirus Network Inspection Service
  2. Windows Defender Antivirus Service

Both will not allow me to stop them and when I double click and get properties Start / Stop / pause and resume are greyed out.

I tried in normal and running Control Panel>Administrator Tools>services in Administrator mode

I also tried in msconfig > services but seems it won’t disable

Any solution ?